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Multiple symmetric lipomatosis (MSL) [excerpts!]
lymph nodes not seen in CT) // differential diagnoses. liposarcoma, Cushing syndrome
Growth of symmetric non-encapsulated masses of adipose tissue mostly around the face and neck, typically:
rapid (!) early development,
followed by slow
progressive growth
of adipose deposits
in and around the face, neck, occipital region,
supraclavicular fossa, + shoulder areas (!)
Complete surgery necessary even if not malignant:
A: Over time,
- neck muscles may become compressed, reduced neck mobility (already started!)
- reducing the size of the trachea and esophagus (!!)
- with associated respiratory obstruction (!!)
- and obstructive sleep apnea! (started, I think)
- Patients also often have (later!) polyneuropathy!! (90%!)
Malignant transformation into liposarcoma has been reported in very rare cases.
→ https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=2398&lng=EN
B: People with multiple symmetric lipomatosis may also develop:[4][1][5]
- Peripheral neuropathy (!!)
- Neurological disturbances including difficulty swallowing, hoarseness (!!)
- sleep problems,
- tachycardia (rapid heart rate),
- fluctuation in blood pressure, and breathing issues
- Other metabolic abnormalities or diseases such as
→ https://rarediseases.info.nih.gov/diseases/6957/multiple-symmetric-lipomatosis
2nd cause: Rare, but possible after only topical corticosteroids:
"Systemic Side-Effects of Topical Corticosteroids" → https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171913/
clobetasol proprionate + betamethasone for several months! (non-healing wounds etc.).
kidney - HPA axis, Cushing Syndrome ...?! h.a.